Mechanisms behind the cell differentiation

The sophisticated mechanisms behind the cell differentiation reveal the fallacies of the evolutionary theory

There are at least 37 trillion cells in a human body. They can roughly be classified into two hundred cell types that our body needs for different tissue types to produce the necessary proteins and to handle several, e.g. metabolism related tasks. All of our cells have exactly the same DNA sequences (only brain neurons and T cells controlled by the immune defense system make an exception). How does the cell differentiation occur? Why does the skin cell have a completely different identity than a bone cell? Both have exactly the same DNA, so it is clear that the DNA sequences do not determine the task or function of the cell.

Differentiation of the cells begins already during embryonic development. The process is called epigenetic reprogramming. If all of the epigenetic markers on the DNA are wiped out of the cell, it becomes a pluripotent stem cell capable of differentiating into any task. During the embryonic development, cells may have to be re-programmed up to two or three times. Only cells programmed by the immune system will not be reprogrammed, which is, of course, a brilliant solution. The most important epigenetic markers affecting cell differentiation are DNA methylation and epigenetic markings of histone, i.e. DNA packaging proteins (including methylation, acetylation, ubiquitination, phosphorylation etc.).

These epigenetic information layers determining cell differentiation are set in epigenetic reprogramming by non-coding RNA molecules. The information transmitted by the MicroRNAs and lncRNAs will be stored in histone epigenetic markers that act as a biological database and an address system. Thus, all information related to the cell function is stored outside of the DNA sequences. In practice, this means activating or suppressing genes and transcriptional regions and bending chromatin to contact certain regions of DNA. As the organism adapts, it experiences the changes in epigenetic information structures. This often results in deleterious DNA sequence changes because methylation acts as a DNA stabilizer. When the methylation profiles change, the cell is exposed to oxidative stress that causes deamination of DNA bases, whereby the base may change. This is where a genetic mutation occurs. This is the most significant mechanism of DNA degradation.

http://www.sciencedirect.com/science/article/pii/S2468054017300021

When the organism adapts to, for example, a new nutritional type or a cooler climate, it is primarily necessary to investigate the changes in epigenetic profiles. DNA sequence changes may also occur, but they are also results of changed epigenetic profiles. Random mutations and natural selection have no role in the ecological adaptation of organisms. If we want to compare the genomic similarity between the two organisms, it should be done between the mechanisms affecting the cell differentiation. Thus, if we compare the human and chimpanzee lncRNA molecules, which set up the biological address database in the embryonic development, are the fallacies of the evolutionary theory revealed: The similarity of human and chimpanzee lncRNA molecules is only 29.8% !! So we're not related to apes. The evolutionary theory is the most serious heresy of our time. Don't get lost, good people.

Comments

Post a Comment

Popular posts from this blog

Previous Sexual Partners Can Influence Another Male's Offspring

Image
Telegony (microchimerism) is not studied by pseudoscientists because it refutes the theory of evolution http://www.theneonnettle.com/features/1006-study-women-store-dna-from-every-male-they-have-sex-with "A new study by the University of Seattle and the Fred Hutchinson Cancer Research Center has revealed that Women absorb and retain living DNA of every single man they have sex with. When scientists were trying to determine if women who had been pregnant with a son might be more predisposed to diseases usually found in men, then also found in the study that the female brain also absorbs male DNA." "Le Dantec wrote that some farmer told him that once his swine copulated with a boar and their pigs absolutely resembled the father in color. But when the same swine copulated with another boar some pigs of the second farrow still resembled the color of the male pig the swine had copulated first."   http://modernnotion.com/is-telegony-real/ "Scientists believe the phe
Read more

Early-stage embryos with abnormalities can still develop into healthy babies

Image
Early-stage embryos with abnormalities can still develop into healthy babies http://www.sanger.ac.uk/news/view/early-stage-embryos-abnormalities-can-still-develop-healthy-babies Excerpt: "Abnormal cells in the early embryo are not necessarily a sign that a baby will be born with a birth defect such as Down’s syndrome, suggests new research from the University of Cambridge, the Wellcome Trust Sanger Institute and the University of Leuven, Belgium. In a study published today (29 March) in the journal Nature Communications, scientists show that abnormal cells are eliminated and replaced by healthy cells, repairing – and in many cases completely fixing – the embryo. Researchers at the Department of Physiology, Development and Neuroscience at Cambridge report a mouse model of aneuploidy, where some cells in the embryo contain an abnormal number of chromosomes. Normally, each cell in the human embryo should contain 23 pairs of chromosomes (22 pairs of chromosomes and one pair of sex chr
Read more

Rapid human genetic degradation

Image
Millions Of Novel Genetic Variants Found In 1000 Swedish Individuals https://scienmag.com/millions-of-novel-genetic-variants-found-in-1000-swedish-individuals/ Excerpt: "An extensive exercise to map genetic variation in Sweden has found 33 million genetic variants, 10 million of which are novel. Large-scale DNA sequencing methods were used to analyse the whole genome of 1000 individuals from different parts of the country. The study was led by researchers at Uppsala University, who have published their findings in the European Journal of Human Genetics. "This resource will benefit many national research projects investigating the association between genetic variants and diseases," says Professor Ulf Gyllensten, Uppsala University and SciLifeLab, who has led the project.   The data will also be of immediate use in clinical diagnostics to determine whether a genetic variation in a patient is a cause of disease, or if it is also present among healthy individuals in the popu
Read more