Sulforaphane in broccoli sprouts found to improve glucose levels in diabetics

Eating raw veggies best for balancing your genome

https://medicalxpress.com/news/2017-06-sulforaphane-broccoli-glucose-diabetics.html

Excerpt: "A team of researchers from Sweden, the U.S. and Switzerland has found that treating rat liver cells with a compound called sulforaphane, which is found in cruciferous vegetables, reduced production of glucose. In their paper published in Science Translational Medicine, the group outlines the methods they used to isolate the compound and what they found when testing it with liver cells and in human patients.

Type 2 diabetes has been in the news a lot in the past several years due to its ties to the obesity epidemic in several countries, particularly the U.S. Prior research has shown that it is a condition in which the body mishandles glucose—cells fail to use insulin properly, leading to higher glucose levels, which can cause a wide variety of health problems. Current treatment includes modifying the diet and taking drugs such as metformin. But because the drugs used to treat diabetes can cause other problems, such as liver damage, researchers continue to look for alternatives. In this new effort, the researchers sought to find a compound that could alleviate symptoms in a more natural way. They created a genetic signature for the disease based on 50 genes that have previously been linked to the disorder and fed the results into a database, which used the genetic signature to look for compounds specifically related to gene expression in liver cells—sulforaphane showed the strongest known effects.
 
The researchers then cultured liver cells from rats with type 2 diabetes and applied sulforaphane to see what would happen—doing so caused the cells to produce less glucose. Optimistic about their results, the researchers next tested the compound on 97 obese human volunteers with type 2 diabetes over a 12-week period—this was possible because sulforaphane is a compound naturally occurring in cruciferous vegetables such as broccoli sprouts. The researchers report that those given the compound showed a significant reduction in glucose levels (while fasting).

The researchers acknowledge that their results are preliminary and that more testing of the compound will be needed to prove that the compound or simply eating the right vegetables might someday replace drugs used to treat type 2 diabetes. They note also that their technique for discovering the compound's usefulness in treating the disease could very well be applied to other diseases."

My comment: Broccoli contains sulphoraphane (C6H11NOS2) which is broken down into methyl groups and other important compounds in the gut. DNA, histones and long non-coding RNA-molecules need these CH3 groups for their epigenetic markers. These are used for correct and successful gene expression and several regulatory functions in our cells. Lack of methyl and abnormal methylation profiles are linked to unsuccessful cellular differentiation and malignant cellular behavior. This means diseases. Diet changes our genomes and poor nutrition exposes our genome to genetic errors.

Life is not driven by gene sequences. Genes are driven by lifestyle. There is no such a thing as mutation driven evolution. Don't get misled.

https://www.healthdiaries.com/eatthis/10-foods-with-sulforaphane.html

Comments

Post a Comment

Popular posts from this blog

Previous Sexual Partners Can Influence Another Male's Offspring

Image
Telegony (microchimerism) is not studied by pseudoscientists because it refutes the theory of evolution http://www.theneonnettle.com/features/1006-study-women-store-dna-from-every-male-they-have-sex-with "A new study by the University of Seattle and the Fred Hutchinson Cancer Research Center has revealed that Women absorb and retain living DNA of every single man they have sex with. When scientists were trying to determine if women who had been pregnant with a son might be more predisposed to diseases usually found in men, then also found in the study that the female brain also absorbs male DNA." "Le Dantec wrote that some farmer told him that once his swine copulated with a boar and their pigs absolutely resembled the father in color. But when the same swine copulated with another boar some pigs of the second farrow still resembled the color of the male pig the swine had copulated first."   http://modernnotion.com/is-telegony-real/ "Scientists believe the phe...
Read more

Early-stage embryos with abnormalities can still develop into healthy babies

Image
Early-stage embryos with abnormalities can still develop into healthy babies http://www.sanger.ac.uk/news/view/early-stage-embryos-abnormalities-can-still-develop-healthy-babies Excerpt: "Abnormal cells in the early embryo are not necessarily a sign that a baby will be born with a birth defect such as Down’s syndrome, suggests new research from the University of Cambridge, the Wellcome Trust Sanger Institute and the University of Leuven, Belgium. In a study published today (29 March) in the journal Nature Communications, scientists show that abnormal cells are eliminated and replaced by healthy cells, repairing – and in many cases completely fixing – the embryo. Researchers at the Department of Physiology, Development and Neuroscience at Cambridge report a mouse model of aneuploidy, where some cells in the embryo contain an abnormal number of chromosomes. Normally, each cell in the human embryo should contain 23 pairs of chromosomes (22 pairs of chromosomes and one pair of sex chr...
Read more

DNA methylation is directed by RNA

Image
Cellular differentiation, adaptation and variation of organisms is directed by RNA, not DNA https://www.researchgate.net/publication/24312289_RNA-directed_DNA_methylation_and_demethylation_in_plants Excerpt: "RNA-directed DNA methylation (RdDM) is a nuclear process in which small interfering RNAs (siRNAs) direct the cytosine methylation of DNA sequences that are complementary to the siRNAs. In plants, double stranded-RNAs (dsRNAs) generated by RNA-dependent RNA polymerase 2 (RDR2) serve as precursors for Dicer-like 3 dependent biogenesis of 24-nt siRNAs. Plant specific RNA polymerase IV (Pol IV) is presumed to generate the initial RNA transcripts that are substrates for RDR2. siRNAs are loaded onto an argonaute4-containing RISC (RNA-induced silencing complex) that targets the de novo DNA methyltransferase DRM2 to RdDM target loci." My comment: There are only a few chemical modifications discovered on the DNA and histones; especially methylation and acetylation. But the list o...
Read more