Genes are no master controllers of life

Turning off the same gene in mice can result in different physical changes, despite similar genetic backgrounds


Excerpt: "A large-scale study, published in Wellcome Open Research and which passed peer review today, has shown that inactivating the same gene in mouse embryos that are virtually genetically identical can result in a wide range of different physical features or abnormalities. This suggests that the relationship between gene mutation and consequence is more complex than previously suspected.

The researchers, from the Deciphering the Mechanisms of Development Disorders (DMDD) consortium that is coordinated at the Francis Crick Institute, looked at 220 mouse embryos each missing one of 42 different genes. By scanning the entire embryo in minute detail, the researchers picked up on even the smallest differences in features – right down to the level of whether the structure of individual nerves, muscles and small blood vessels were abnormal.

The genes studied by DMDD are known as ‘embryonic lethal’, because they are so crucial to development that an embryo missing any one of them can’t survive to birth. Studying these genes can help us understand how embryos develop, why some miscarry, and why some mutations can lead to abnormalities at birth.

Clinicians commonly find that people with the same genetic disease can show different symptoms or be affected with differing severity. In part this is likely to be due to the fact that we all differ in our precise genetic makeup. However, this study in mice shows that even when individuals have virtually identical genomes, the same mutation can lead to a variety of different outcomes amongst affected embryos.
“This is a striking result, coming as it does from such a large study in which embryos have been studied in unprecedented detail. It shows us that even with an apparently simple and well-defined mutation, the precise outcome can be both complex and variable. We have a lot to learn about the roles of these lethal genes in embryonic development to understand why this happens.
“This is a surprising result, and more research into gene function is needed in order to make sense of the finding.”
Dr Tim Mohun, who led the study at Deciphering the Mechanisms of Developmental Disorders (DMDD)"

My comment: They didn't take into account the several forms of biological information. And they didn't take into account that control of embryonic cell development is not guided by genes inside the embryo, but several epigenetic mechanisms outside the embryo.

When they can't prove that whole gene knockouts affect certain traits, then how come could they prove that small point mutations affect certain traits? This is why all claims regarding point mutations induced gene alleles and their assumed impact on traits are now questionised.

Evolutionists have a serious Missing Heritability problem. Life is not driven by gene sequences. Genes are driven by lifestyle. The evolutionary theory is a major heresy. Don't get misled.

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