Genetic variation will not lead to evolution

Scientists Make Connection Between Genetic Variation and Immune System in Risk for Neurodegenerative and Other Diseases


Excerpt: "The researchers recruited a subset of 461 volunteers from the PhenoGenetic Project of African American, East Asian American, or European American ancestry. Two different types of immune cells — T cells and monocytes — were purified from each individual's blood, representing the adaptive and innate arms of immunity, respectively. The researchers profiled these cells to measure the expression of 19,114 genes in each cell type. They then examined genetic variants throughout the human genome for their effects on gene expression in these two representative populations of immune cells.

They discovered that genetic variation influencing a person's risk for multiple sclerosis, rheumatoid arthritis, and type 1 diabetes is more likely to control gene activity in T cells than in monocytes. In contrast, genetic variation that increases one's risk for neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, shows a striking enrichment of functional effects in monocytes."

My comment: Gene sequence alterations occur, that's true. But random base pair substitutions, genetic errors and mistakes never lead to evolution. However, base pairs can sometimes change due to mechanisms involved typically in the immune system. These one nucleotide level alterations never lead to evolution. For assumed large scale evolution you need new genes that are introduced for complex gene regulatory networks. You also need information how these genes are to be expressed and how several complex regulatory factors interact with them. Large scale evolution has never been observed because it is not possible to happen. Genetic variation is associated with genomic degradation and this is something we can observe:

http://www.who.int/genomics/public/geneticdiseases/en/index2.html

"Monogenic diseases result from modifications in a single gene occurring in all cells of the body. Though relatively rare, they affect millions of people worldwide. Scientists currently estimate that over 10,000 of human diseases are known to be monogenic. Pure genetic diseases are caused by a single error in a single gene in the human DNA."

Over 10,000 genetic diseases point out the impossibility of evolution. Don't get misled.

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