Science Refutes Creationism

A Novel Combination of Withaferin A and Sulforaphane have numerous anti-cancer effects http://www.bioportfolio.com/resources/pmarticle/1757328/A-Novel-Combination-of-Withaferin-A-and-Sulforaphane-Inhibits-Epigenetic-Machinery-Cellular.html?utm_source=dlvr.it&utm_medium=twitter Excerpt: "With cancer often classified as a disease that has an important epigenetic component, natural compounds that have the ability to regulate the epigenome become ideal candidates for study. Humans have a complex diet, which illustrates the need to elucidate the mechanisms of interaction between these bioactive compounds in combination.    The natural compounds withaferin A (WA), from the Indian winter cherry , and sulforaphane (SFN), from cruciferous vegetables , have numerous anti-cancer effects and some report their ability to regulate epigenetic processes. Our study is the first to investigate the combinatorial effects of low physiologically achievable concentrations of WA and SFN on bre...

Bacterial sense of smell - Incredible mechanism https://www.technologynetworks.com/proteomics/news/scientists-investigate-bacterial-sense-of-smell-288948 Excerpt: "Scientists from MIPT, in collaboration with their colleagues from the Forschungszentrum Jülich, the Institut de Biologie Structurale (IBS) and European Synchrotron Radiation Facility (ESRF) in Grenoble, have proposed a universal mechanism for the “sense of smell” in bacteria. This was done by obtaining the structure of the NarQ protein from Escherichia coli (E. coli) – which belongs to a universal class of sensory histidine kinases that are responsible for transmitting signals to bacteria about their environment. The paper published in Science will help us understand how bacteria “communicate” with one another and form biofilms on sterile surfaces or inside the human body. Drugs which affect bacteria’s “sense of smell” could potentially be used as substitutes for modern antibiotics. They do not kill bacteria; they simpl...

Engineering Protein Stability with Atomic Precision https://www.technologynetworks.com/proteomics/news/engineering-protein-stability-with-atomic-precision-288982 Excerpt: "Proteins are the workhorses of biology. For example, they help convert light energy into sugar in plants, transport oxygen from our lungs to our muscles, and combine sugar and oxygen to release energy to make the muscles work. To perform these tasks, proteins must adopt specific 3D structures, called protein folds. In chemical terms, proteins are polymers, or strings of amino acids, much like the beads of a necklace. There are 20 different chemistries of the amino-acid building blocks. It is the combination of these along the protein string that determines how a protein folds up into its functional 3D shape. Despite decades of effort, scientists still don’t understand how biology achieves this protein-folding process, or, once folded, how protein structures are stabilised.   To address this problem, the Brist...

Checklist to confirm Biblical Creation and Intelligent Design - And to refute the theory of evolution Things we are expected to observe whether Biblical creation and the global flood could be regarded as a potential theory for explaining the origin of life and the rich biodiversity. Here's the updated checklist.   1. No pre-cellular life forms have been observed. Check. 2. Unicellular life form has not been observed to evolve into multicellularity. Check. 3. Bacteria stay bacteria, dogs stay dogs etc. Check. 4. Large scale evolution has not been observed to happen. Check. 5. Organisms are able to rapidly adapt due to very sophisticated epigenetic mechanisms. Check. 6. Organisms may experience variation after adaptation. Check. 7. Variation modifies mating behaviour. Check. 8. Random genetic errors don't impact the biodiversity. Check. 9. There are a wide variety of efficient repair mechanisms in cells. Check. 10. A lot of rapidly buried organisms can be found in sediment layers...

Top six cancer fighting superfoods http://www.health.com/health/gallery/0,,20430736,00.html Excerpt: "To reduce your risk of cancer, look no further than your fridge. "All the studies on cancer and nutrition point to eating plant-based foods for their phytonutrients and other special compounds," says Richard Béliveau, PhD, chair in the prevention and treatment of cancer at the University of Québec at Montreal and author of Foods to Fight Cancer. Aim for five to nine daily servings of all kinds of fruits and vegetables—especially these six superstars.   Tomatoes This juicy fruit is the best dietary source of lycopene, a carotenoid that gives tomatoes their red hue, Béliveau says. And that's good news, because lycopene was found to stop endometrial cancer cell growth in a study in Nutrition and Cancer. Endometrial cancer causes nearly 8,000 deaths a year. Helps fight:  endometrial, lung, prostate, and stomach cancers Your Rx:  The biggest benefits come from cooked toma...

Traits are not determined by gene sequences - Epigenetic information layer is used for cellular differentiation Each of our cells has the same gene sequences. However, there are hundreds of different cell types in our bodies. By which mechanism is a skin cell specialized into its own function? Why does a nerve cell have its own identity? Hundreds of different cell types are capable of producing hundreds of thousands of different proteins even though they have the same gene sequences. How is this possible? There are several forms of biological information in our cells. Gene sequences constitute a digital body and a platform for other forms of biological information. For their successful differentiation, the cells need a specific information layer that functions on top of the genes. This kind of information is called epigenetic control of gene expression. If the epigenetic information layer is removed from the cell, it becomes a pluripotent stem cell that is in an open state to specializ...

European robin is able to maintain a quantum state longer than scientists in labs https://www.newscientist.com/article/mg20927963-000-quantum-states-last-longer-in-birds-eyes/ Excerpt: "A process called the radical pair (RP) mechanism is believed to be behind the latter method. In this mechanism, light excites two electrons on one molecule and shunts one of them onto a second molecule. Although the two electrons are separated, their spins are linked through quantum entanglement. The electrons eventually relax, destroying this quantum state. Before this happens, however, Earth’s magnetic field can alter the relative alignment of the electrons’ spins, which in turn alters the chemical properties of the molecules involved. A bird could then use the concentrations of chemicals at different points on its eye to deduce its orientation. Intrigued by the idea that, if the RP mechanism is correct, a delicate quantum state can survive a busy place like the back of an eye, Erik Gauger of the...

Not random mutations but epigenetic adaptation of stickleback to marine and freshwater conditions https://academic.oup.com/mbe/article-abstract/doi/10.1093/molbev/msx156/3813257/Genome-wide-DNA-methylation-profiling-reveals?redirectedFrom=fulltext Excerpt from abstract: "The three-spined stickleback (Gasterosteus aculeatus) represents a convenient model to study microevolution - adaptation to a freshwater environment. While genetic adaptations to freshwater environments are well-studied, epigenetic adaptations have attracted little attention. In this work, we investigated the role of DNA methylation in the adaptation of the marine stickleback population to freshwater conditions. DNA methylation profiling was performed in marine and freshwater populations of sticklebacks, as well as in marine sticklebacks placed into a freshwater environment and freshwater sticklebacks placed into seawater. We showed that the DNA methylation profile after placing a marine stickleback into fresh wat...

The most inconvenient findings that refute the theory of evolution http://www.genesisalive.com/flood-artifacts.html   Nampa Image,  2 million charlie-years Wright, Frederick, G. American Antiquarian 11:379-381 1889 and Scientific American, Nov. 9, 1889. An Image from Nampa, Idaho area was brought to the surface in a well drilling operation in 1889. The stone doll came from the 300-foot level of a well boring. “The record of the well shows that in reaching the stratum from which the image was brought up they had penetrated first about fifty feet of soil, then about fifteen feet of basalt, and afterwards passed through alternate beds of clay and quicksand down to a depth of about three hundred feet, when the sand pump began to bring up numerous clay balls, some of them more than two inches in diameter, densely coated with iron oxide." According to the United States Geological Survey the age of this strata "Plio-Pleistocene” of 2 million years ago using non-catastrophic measurem...

Randomness has no role in biodiversity https://phys.org/news/2017-05-cells-ratios-gene.html#nRlv Excerpt : " In multicellular animals, cells communicate by emitting and receiving proteins, a process called signaling. One of the most common signaling pathways is the transforming growth factor b (Tgf-b) pathway, which functions in all animal species throughout their lifetimes and regulates numerous biological processes, such as instructing cells how to differentiate—whether a stem cell will become a muscle cell or a bone cell, for example. But how do cells decipher those signals and use that information to guide gene expression? The answer, according to new research from the laboratory of Lea Goentoro, assistant professor of biology at Caltech: the cells perform simple division. In other words, they do math.   The cell's detection of the Tgf-b signal triggers a series of molecular interactions, culminating in changes in the abundance of a protein called Smad3. A kind of messenge...

If all of the people with rare genetic diseases lived in one country, it would be the world’s 3rd most populous country https://globalgenes.org/rare-diseases-facts-statistics/ Statistics and Figures on Prevalence of Genetic and Rare Diseases Although rare and genetic diseases, and many times the symptoms, are uncommon to most doctors, rare diseases as a whole represent a large medical challenge. Combine this with the lack of financial or market incentives to treat or cure rare diseases, and you have a serious public health problem. Here are a few statistics and facts to illustrate the breadth of the rare disease problem worldwide: - There are approximately 7,000 different types of rare diseases and disorders, with more being discovered each day - 30 million people in the United States are living with rare diseases. This equates to 1 in 10 Americans or 10% of the U.S. population - Similar to the United States, Europe has approximately 30 million people living with rare diseases. It...

Epigenetic markers strongly affect binding of transcription factors http://www.genengnews.com/gen-news-highlights/epigenetic-marks-shun-some-transcription-factors-embrace-others/81254309?utm_medium=newsletter Excerpt: "The same epigenetic marks can be read as “keep off” or “welcome,” depending on what DNA-binding protein, or transcription factor, is doing the reading. These marks, methylated cytosine and guanine dinucleotides (mCpGs), normally indicate which portions of the genome are inactive. But new findings from a systematic study of hundreds of transcription factors suggest that mCpGs may play a more subtle role in gene regulation. In this new study, scientists based at Karolinska Institutet systematically analyzed the binding specificities of transcription factors to DNA that was marked by mCpGs, as well as to DNA that was unmarked by mCpGs. The observed that mCpGs can influence binding of most transcription factors to DNA—in some cases negatively and in others positively. I...

Forget about designer babies - You can screen for genetic diseases but not for traits https://phys.org/news/2017-02-ethicists-day-heredity-disease.html Excerpt: "Don't expect designer babies any time soon—but a major new ethics report leaves open the possibility of one day altering human heredity to fight genetic diseases, with stringent oversight, using new tools that precisely edit genes inside living cells. What's called genome editing already is transforming biological research, and being used to develop treatments for patients struggling with a range of diseases. The science is nowhere near ready for a huge next step that raises ethical questions—altering sperm, eggs or embryos so that babies don't inherit a disease that runs in the family, says a report Tuesday from the National Academy of Sciences and National Academy of Medicine. But if scientists learn how to safely pass alterations of the genetic code to future generations, the panel said "germline"...